From Tuesday 4 January 2022 an amended service pattern will operate on the following routes:
| West and Central Region | Route affected and services withdrawn |
| Barrow – Manchester Airport | 3 services in each direction will not be operating:
07:28 Airport-Barrow 04:55 Barrow-Airport |
| Barrow-in-Furness – Carlisle | 2 services in each direction will not be operating:
06:19 Carlisle-Barrow 10:22 Barrow-Carlisle |
| Preston – Victoria | Service withdrawn (Chorley to Horwich Off Peak rail replacement) |
| Liverpool – Manchester Airport via Warrington Central | Service withdrawn : Customers are advised to use other services still operating on the route |
| Preston – Colne | Service reduced from hourly to mix of hourly and two hourly |
| Preston – Blackpool South | |
| Preston – Ormskirk | |
| Manchester Piccadilly – Buxton | Peak additional services withdrawn |
| Manchester Piccadilly – Sheffield via New Mills Central | 1 service withdrawn in each direction
1249 Piccadilly to Sheffield 1414 Sheffield to Piccadilly |
| Manchester Piccadilly – New Mills Central | 3 services withdrawn in each direction
0611 Piccadilly to New Mills Central 1719 Piccadilly to New Mills Central 1919 Piccadilly to New Mills Central
0726 New Mills Central to Piccadilly 1836 New Mills Central to Piccadilly 2034 New Mills Central to Piccadilly |
| Manchester Piccadilly – Rose Hill | 1 service withdrawn in each direction
1540 Piccadilly to Rose Hill 1614 Rose Hill to Piccadilly |
| Manchester Piccadilly – Hadfield | Mix of hourly and half hourly |
| Kirkby – Wigan – Victoria – Blackburn via Todmorden | Two hour gap every 5 hours |
| Liverpool – Blackpool | Mix of hourly and two hourly |
| Liverpool – Warrington Bank Quay | Service withdrawn : Customers are advised to use other services still operating on the route |